Yintoni i-Metformin, iimpembelelo ezingasetyenziswayo, kunye nokuba kutheni isetyenziselwa ukungafihli
I-Metformin iyisisulu esishukumisayo se-insulin esetyenziswa ngokuyinhloko ekuphatheni isifo sikashukela, kodwa sinokusetyenziswa ukuzala. Abasetyhini abane-PCOS banokuzuza ngokuthatha i-metformin yodwa, kunye ne-Clomid, okanye kwinyanga yokwelashwa kwe-IVF. Ngokuchanekileyo indlela i-metformin ephucula ngayo ukuvelisa ngokucacileyo.
Nangona i-metformin ingasetyenziselwa unyango lokungabikho komntwana , akusiyo isiyobisi sokuzala.
Enyanisweni, ukuyisebenzisa ukunyanga ukungabikho komntwana kuthathwa njenge-off-label usetyenziso. (Ngamanye amazwi, ukuphumelela kokukhulelwa akuyona injongo yentsusa ejoliswe kuyo yile nkunkuma.)
Yintoni le mayeza? Yaye unokukunceda njani ukuba ukhulelwe?
Yintoni i-Metformin?
Ukuze uqonde oko i-metformin yenzayo, kufuneka uqale ukwazi ukuba ukuphikiswa kwe-insulin. Abasetyhini abaninzi abane-PCOS banokuxhathisa i-insulin. Ukuxhathisa kwe-insulin yilapho iiseli zomzimba ziyeke ukuphendula kumazinga aqhelekileyo e-insulin. Bathi bangacineli, okanye baxhatshazwa.
Ngenxa yoko, umzimba ucinga ukuba ayikho i-insulin eyaneleyo kwinkqubo. Oku kubangela ukuveliswa kwe-insulin ngaphezulu kunokuba umzimba wakho udinga.
Kubonakala kubakho ukuxhamla phakathi kwe-insulin kunye ne-hormone yokuzala. Ngoxa kungekho mntu uqiniseke ngokuchanekileyo ukuba ezi zimbini zidibene njani, amanqanaba e-insulin abonakala ekhokelela kumanqanaba okwanda kwama-androgens.
Amadoda nabasetyhini banama-androgens, kodwa i-androgens ngokuqhelekileyo icinga ukuba "ihomoni zamadoda." Amanqanaba aphezulu e-androgen akhokelela kwiimpawu zePCOS kunye neengxaki nge-ovulation.
I-Metformin kunye neminye imithi evuselela i-insulin ephantsi kwezinga le-insulin emzimbeni. Ngaphandle kwe-metformin, i-rosiglitazone kunye ne-pioglitazone yilezi ezinye iziyobisi ezingasetyenziswa ekuphatheni i-PCOS.
Kutheni i-Metformin isetyenziselwa ukuphatha ii-PCOS?
Kukho izizathu ezinobangela ukuba ugqirha wakho angamisela i-metformin xa unyanga i-PCOS yakho, ezinye zazo zihlobene nokuzala:
Ukunyuswa kwe-insulin
Njengoko kuchaziwe ngasentla, ukuxhathisa i-insulin kuqhelekileyo kubasetyhini abane-PCOS.
I-Metformin inokumiselwa ukunyanga ukuxhatshazwa kwe-insulin, enokuncedisa ukulawula i-hormone yokuzala nokuqalisa kwakhona ukuvuthwa.
Ukukhutshwa kwe-Ovulation Induction
Olunye uphando malunga ne-metformin kunye ne-PCOS lubonisa ukuba imijikelezo yesini ibe yinto ephindaphindiweyo kwaye i-ovulation ibuya ngokunyangwa kwe-metformin. Oku kwenzeka ngaphandle kokudinga iziyobisi ezinjenge- Clomid .
Nangona kunjalo, ezinye zophando zophando azifumananga inzuzo yokuthatha i-metformin.
Ngenxa yoko, abanye oogqirha bacebisa ukuba i-metformin isetyenziswe kuphela ukuphatha abafazi abangenakukhuseleka kwe-insulini kwaye kungekhona bonke abafazi abane-PCOS kungakhathaliseki ukuba ngaba bengenakuphikiswa kwe-insulin okanye cha.
Ukuxhatshazwa kweComidid
Ngoxa i-Clomid iya kunceda abaninzi abafazi nge-PCOS, bafazi abathile banqatshelwe i-Clomid . (Le ndlela yindlela eqhelekileyo yokutsho ukuba ayisebenzi kubo.)
Olunye uphando luye lwafumanisa ukuba ukuthatha i-metformin kwiinyanga ezi-4 ukuya kwezi-6 ngaphambi kokuba uqalise unyango lwe- Clomid lungaphucula impumelelo yabasetyhini abane-Clomid-resistant.
Enye inketho yabasetyhini nge-Clomid ukumelana ne- metformin idibene ne-letrozole .
Iziyobisi ezinobungozi
Ukuba i-Clomid ayikuncedi ukuba ukhulelwe, isinyathelo esilandelayo ngokuqhelekileyo i- gonadotropins okanye iziyobisi zonyango ezingenayo .
Uphando lufumene ukuba i-injection injectables ene-metformin inokuphucula intlawulo ekhulayo.
Olunye uphando lwafumanisa ukuba ukudibanisa i-metformin kunye neyeza kukuphucula izinga lokuzalwa eliphilayo xa lifaniswa nonyango kunye neejectables kuphela. Kule sifundo, ukuba izinga lokuzalwa lokuzalwa kunye neeprojithali kuphela lilingama-27 ekhulwini, unyango kunye ne-metformin kunye ne-injection ziyakwandisa izinga lokuzalwa eliphilayo ukuya kuma-32 ukuya kuma-60 ekhulwini.
Umngcipheko oNcitshiswayo we-Ovarian Hyperstimulation Syndrome
I-Ovarian hyperstimulation syndrome (OHSS) ingozi xa kukho ukusebenzisa iziyobisi zonyango, ingakumbi ngexesha le-IVF. Abasetyhini abane-PCOS banomngcipheko omkhulu wokuphuhlisa i-OHSS.
Ezinye iziphumo ziye zafumanisa ukuba i-metformin inganciphisa ingozi ye-OHSS ngexesha le-IVF. Nangona kunjalo, akucaci ukuba i-OHSS iyancitshiswa kwamanye unyango. Ngokomzekelo, uphando malunga ne-gonadotropins yedwa (ngaphandle kwe-IVF) ayifumananga nantlukwano kumaxabiso akwa-OHSS xa ungeze i-metformin kwiprothokholo yonyango.
Ukutshatyalaliswa kwakhona
Abasetyhini kunye ne-PCOS banokuthi bafumane ukukhulelwa kwesisu kunabantu bonke. I-Metformin inokunciphisa umngcipheko wokuphuphuma komzimba kwabasetyhini abane-PCOS, ngokweminye uphando.
Izifundo ezimbalwa ziye zafumanisa ukuba unyango oluqhubekayo lwe-metformin ngethuba lokuqala lokukhulelwa lunokunceda ukunqanda ukuphazamiseka komzimba kwabasetyhini abane-PCOS.
Nangona kunjalo, ukhuseleko lwe-metformin ngexesha lokukhulelwa alukho kakuhle. Ukugqiba isigqibo sokuthatha i-metformin ngexesha lokukhulelwa ngumngcipheko onokuxubusha ngokugqithiseleyo nodokotela wakho.
Ukulahlekelwa kwesisindo
I-PCOS inxulumene nokukhuluphala. Ukukhungatheka kwabasetyhini abaninzi, ukulahlekelwa isisindo nge-PCOS kunokuba nzima.
Ezinye izifundo zibonise ukuba i-metformin inokunceda abafazi nge-PCOS ukulahlekelwa isisindo. Ekubeni ukulahlekelwa isisindo kuye kwabonakaliswa ukukunceda ukuqala ukuvuthwa kunye nokufikelela ekukhulelweni, ugqirha wakho unokumisela i-metformin, kunye nesicwangciso sokutya kunye nokuzilolonga, ukukunceda ukuphucula ukuzala kwakho.
Ziziphi iimpembelelo?
I-effect ye-Metformin echaphazelekayo yecala isisu, esoloko ihudo, kodwa ngamanye amaxesha iphinda ihlanza kunye nesiphithiphithi. Ukuthatha i-metformin phakathi kwesidlo kunokuncedisa ukunciphisa eli phulo.
Iziphumo ezichaphazelekayo zokugonya zinganciphisa ixesha. Abanye besetyhini bafumana ukuba ukutya okuthe ngqo kubangela ukuba isisu siphumelele ngakumbi kunabanye.
Iziphumo ezibi kakhulu ezinxulumene ne-metformin zinobungozi bentsholongwane kunye nesiphumo esinqabileyo kodwa esinamandla, i-lactic acidosis.
Ngethuba uthabatha i-metformin, ugqirha wakho kufuneka alandele imisebenzi yakho yezintso kunye nesibindi. Abantu abaneentliziyo, isibindi, isifo, okanye isifo sephunga akufanele bathathe i-metformin. Qinisekisa ukubonelela ugqirha wakho ngembali yonyango.
Ukusetyenziswa kwe-metformin ukunyanga ukungabikho kwengqondo ehlobene ne-PCOS isacutshungulwa, kwaye oogqirha abahlukeneyo banemibono ephikisanayo malunga nokuba, nini, kunye nendlela yokusebenzisa i-metformin ukunyanga.
Musa ukwesaba ukuvakalisa ukukhathazeka kwakho kunye nemibuzo kumnikezeli wakho wokunakekela, ukwenzela ukuba kunye, unokugqiba isigqibo sokuba ngaba unyango.
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