Xa Amanxeba Amanxeba Amanxeba, Xa Iyanqanda, kunye Neengozi zoBawo Abadala
Ukuzala komntu kuguquka ngobudala. Unokufumana ingqiqo yokuba iminyaka yobudala ibaluleke kuphela kwimveliso yesetyhini . Nangona utshintsho kwi-fertility lukhulu kakhulu kubafazi, amadoda anamawashi e-biological, nawo.
Xa Ubunzima Bendoda Yenzalo Yobunini Nokuba Iyaphela nini?
Olunye uphando olwenziwa eYunivesithi yaseSoroka e-Israel lubhekiselele kumgangatho weesilisa kumadoda avamile kwaye uthelekisa ubungakanani kunye nomgangatho weesini kumadoda eminyaka.
Uhlolisiso lubhekisele kuyo yonke into yokuhlalutya isisombululo, kuquka kuquka ukuba balala ngesini na. Oku kubalulekile ukuqwalasela ngenxa yokuba ukuzilahla ngokwesondo kunokunciphisa umgangatho wenyama. Ukulala ngesondo rhoqo kudala impilo enempilo.
Abaphengululi bafumanisa ukuba ubuninzi beesilwanyana bavela phakathi kweminyaka engama-30 no-35. (Ngaba le nto ingaba yindlela yemvelo yokuqinisekisa ukuba isibini sithatha ngaphambi kokuba umfazi azalwe kuqala ukuhla kwe-35?) Kwesinye isiphelo sembali, ubuninzi beesilwane ukuba libe ngaphantsi emva kweminyaka yobudala engama-55.
Omdala Umntu, Weaker Abagijimi
Olu pho nonongo lufumene ukuba ubuncinane besilisa buguqulwe ngobudala. I-sperm motility yindlela intlobo yesisu ehamba ngayo.
I-sperm motility yayilungileyo ngaphambi kokudala kweminyaka engama-25 kwaye iphantsi kakhulu emva kweminyaka yobudala engama-55. Enyanisweni, xa kuthelekiswa nenani "lokubhukuda kakuhle" kwidoda phakathi kweminyaka engama-30 ukuya ku-35 kunye namadoda angaphezu kweminyaka engama-55 ubudala, ukukhulelwa kwesidoda kwancipha ngamaphesenti angama-54.
Ezi zintlukwano ezinamandla azikwazanga ukuthethwa ngokuzilahla ngokwesondo, okuye kwalandelwa kwisifundo.
Ukwandisa ingozi yeengxaki ze-Genetic kubantu abadala
Ngaphandle kwezilwanyana ezincinci, ubudala buyakuchukumisa umgangatho wobomi wesilisa.
Kwisifundo esenziwe kwiLebhu yaseLawrence Livermore yeLebhu yeSizwe (LLNL) kunye neYunivesithi yaseCalifornia eBerkeley, abaphandi bafumene ukuba iimpembelelo zofuzo kwindoda yokwanda kunye nobudala kumadoda.
Ezi ziphoso zentlobo zemizimba zingabangela:
- kuncipha ukuzala
- kwandisa ithuba lokukhulelwa kwesisu
- ukwanda komngcipheko wokuzalwa
- ukwanda komngcipheko wesiphene esithile sokuzalwa
Izazi zenzululwazi zabika ukuba amadoda asekhulile asemngciphekweni wokungabikho. Kananjalo banokuthi badlulisele iingxaki zobomi kubantwana babo.
Ukuhlanganiswa kwamabhinqa kunye nobudala besilisa kunokunyusa umngcipheko weziphene zokuzalwa. Thatha umzekelo umngcipheko we-Down syndrome. Kubasetyhini, umngcipheko wokuba nomntwana abane-Down syndrome ukwandisa ngobudala.
Kuhlolisiso lwabantwana abangaphezulu kwe-3,000, abaphandi bafumanisa ukuba xa ibhinqa lineminyaka engama-35 okanye ngaphezulu, ubudala bomntu bubaluleke kakhulu.
Oku kwakunyanisekileyo xa loo ntokazi yayineminyaka engama-40 okanye ngaphezulu. Kule qela, iipesenti ezingama-50 zabantwana abane-Down syndrome zifumene ukuba i-defect genetic in the side of their father side.
I-Down syndrome ayiyona yingozi nje yonyuka ngokuzalwa komntwana.
Ootata abakhulileyo banako ukuba nabantwana abanalo:
- autism
- ukuxhuzula
- schizophrenia
- i-achondroplasia, uhlobo oluthile lomzimba
le ntsholongwane
Khawucinge ngobudlelwane beMadoda nabasetyhini ndawonye
Kuthatha amabini ukwenza umntwana. Ngelixa singakwazi ukugxila kwixesha lomntu kunye nobudala bomfazi, kubalulekile ukuqwalasela indlela abadibanisa ngayo.
Uhlolisiso lwezibini ezingu-782 ziphande ukuba zeziphi iingxaki zokukhulelwa ezisekelwe kwiminyaka yobudala nokuba ingaba nesondo ngosuku lwabo oluvundisayo (nje ngaphambi kokuvutha.)
Bafumene ukwehla okucacileyo kwenzalo ngokusekelwe kwiminyaka yobufazi.
Kwabesetyhini abaneminyaka eli-19 ukuya kuma-26, babe neepesenti ezingama-50 zokukhulelwa ngosuku lwabo oluvundileyo. Abafazi abaneminyaka engama-35 ukuya ku-39 banamathuba angama-29 kuphela.
Nangona kunjalo, into ebalulekileyo kunayo yempembelelo yobudala besilisa. Kuyabasetyhini abaneminyaka engama-35 ukuya ku-39, ukuba le ndoda yayineminyaka emihlanu okanye ngaphezulu emdala kunowesifazane, iingxaki zabo zokuphumelela ekukhulelweni ziyehla kuma-15 ekhulwini. Iingxaki ezininzi zinqunywe kwisiqingatha.
Ukuphumelela kweMadoda kunye ne-IVF
Kuthiwani ngendima yenkwenkwe yamadoda kunye neempembelelo zonyango lwe-IVF ? Uphando olusondeleyo lubonise ukuba amazinga okuphumelela kwe-IVF ayenokuchaphazeleka kakubi ngabantu abadala.
Nangona kunjalo, uphando olongezelelweyo lufumene ukuba ukusebenzisa iteknoloji ye-ICSI inokukwazi ukunqoba nayiphi na inzuzo ebudaleni.
Uphononongo olunye lubukele ngokuphindaphindiweyo kwimijikelezo engaphezu kwe-2 500 ye-IVF eyasebenzisa i-ICSI. I-ICSI igxininisa i-intracytoplasmic sperm injection. I-ICSI iquka ukujoba isilwanyana sesinqa ngqo kwiqanda. Abaphandi bafumene ukuba ubudala bendoda buyanciphisa inani leembryo eziphezulu, kodwa akuzange kubangele izinga lokukhulelwa, okanye ukwandisa umngcipheko wokuzalwa kwangaphambili okanye ukulahleka kokukhulelwa.
Olunye uvavanyo-lo ukhangele malunga ne-4 800 ijikelezo-wayejonga ngokusebenzisa amaqanda abanikeli kwi-IVF-ICSI cycle. Kule sifundo, onke amaqanda abanikeli abavela kuma-36 ubudala okanye abatsha.
Abaphengululi bafumanisa ukuba ukubala kwamabhinqa, ukuxininisa kunye nokuhamba (ukunyakaza) kuye kwancipha. Kodwa, xa kufikelele kwinjongo ephambili-ukukhulelwa nokuzala-amanani ayilungile. Ubudala bomntwana obusondeleyo abuzange bubize amazinga okuphumelela.
Kubalulekile ukukhumbuza ukuba ezi ziphumo azikwazi ukuveliswa ngabantu abangasebenzisi ii-IVF, okanye abo bangasebenzisi ii-IVF nge-ICSI. Nge-ICSI, isidoda akudingeki ukuba ibhukude kakuhle okanye ingene kwiqanda ngokwabo. Bobabini bayadingeka ngokuveliswa kwemvelo kunye ne-IVF ngaphandle kwe-ICSI.
Inqaku elibhekiselele kwiZenzalo zobuntu kunye nobudala
Ubudala bomntu bubalulekile. Amadoda angenayo inkunkuma epheleleyo kwi-fertility efana nabasetyhini. Kodwa "ubudala bomntwana obusondeleyo" yinto ethile imibhangqwana kufuneka iyazi.
Bobabini abesilisa nabasetyhini kufuneka balwe namaxesha abo.
Imithombo:
> Beguería R1, García D2, Obradors A1, Poisot F1, Vassena R3, Vernaeve V4. "Ubudala bobazali kwaye bancedisa iziphumo zokuzala kwii-oocytes zabanikeli be-ICSI: ngaba kukho umphumo wobawo asebekhulile? " Uhlambalaza . 2014 Oktobha 10; 29 (10): 2114-22. i-doi: 10.1093 / i-humrep / deu189. Epub 2014 Julayi 28.
UDunson DB, iColombo B, iBaird DD. "Utshintsho kunye nobudala kwinqanaba kunye nobude bokukhula kwimijikelezo yokuya esikhathini." U- Hum Reprod. Ngo-2002 uMeyi; 17 (5): 1399-403.
Fisch H1, Hyun G, Golden R, Hensle TW, Olsson CA, Liberson GL. "Impembelelo yobudala bomntwana ekuhlaleni kwe-syndrome. "J Urol. 2003 Juni; 169 (6): 2275-8.
Lawson G1, iFletcher R2. "Ukutshatyalaliswa koyise. "I-N Fam Plann Inkathalo yezoMpilo. 2014 Oct; 40 (4): 283-8. i-doi: 10.1136 / jfprhc-2013-100866. Epub 2014 Juni 23.
> Wu Y1,2,3, Kang X1, Zheng H1, Liu H1, Huang Q1, Liu J1. Umphumo wobudala bomntwana kwimiphumo yokuzalisa i-Intracytoplasmic Sperm Injection. "PLoS One. 2016 Feb 22; 11 (2): e0149867. i-doi: 10.1371 / iphephandaba.pone.0149867. eCollection 2016.