Kutheni i-heparin ne-aspirin inokunceda
Xa igazi lakho livale, ezininzi zeeprotheni emzimbeni wakho, phakathi kwazo i-Factor V, zisebenza kunye ukwenza oko kwenzeke; I-Factor V Leiden yintlukwano yofuzo lwe-Factor V echaphazela inkqubo yokwenza i-blood clotting kwaye yenza ukuba umntu akwazi ukudala i-blood clots.
Funda kabanzi malunga nokuhlukahluka kwemfuza kunye nokuba yeyiphi impembelelo enokuba nayo xa ukhulelwa ngoku kuhlaziywa.
Iikopi ze Factor V Leiden Gene
Umntu unokufumana ikopi enye ye-Factor V Leiden geni kunye nekopi eqhelekileyo (ithetha ukuba umntu u-heterozygous), okanye umntu unokufumana iikopi ezimbini ze-Factor V Leiden geni (umntu u-homozygous).
Abanye oogqirha bacebisa i-heparin kubafazi abanesifo sengqondo esiphindayo esilungileyo esilungileyo kwi-Factor V Leiden. Buza ugqirha wakho ukuba uthetha i-heparin, enye iyeza okanye akukho nyeza kuye.
Ukunyanzelwa kwamaprotheni C
I-Factor V ye-Leiden geni idibaniswa neemeko ezibizwa ngokuba yi-protein C. Iprotheni C enye iprotheyini ebandakanyekayo kwinkqubo yokucima. Ubuninzi babantu abane-protein ye-protein C ebenziwe nayo i-Factor V Leiden yohlobo lwezofuzo. Ngoko ke, abaninzi abasetyhini abangakhange bavavanywe ngokuthe ngqo kwi-Factor V Leiden geni bangafumanisa ukuba bayithwala emva kokuvavanya kwiprotheni C.
Izibalo
Phantse iipesenti ezi-4 ukuya kuma-7 ekhulwini labantu li-heterozygous kwi-Factor V Leiden.
Phantsi kwimizuzu engama-0.06 ukuya kwi-0.25 ekhulwini yabemi i-homozygous for Factor V Leiden. Amaqela eentlanga ezahlukeneyo anamazinga ahlukeneyo okuguquguquka kwe-Factor V Leiden; Kuqhelekileyo kubantu abavela kumpuma kweYurophu. Thetha ugqirha wakho malunga nokuba ungasengozini okanye awukho.
Mngcipheko
I-Factor V Leiden ithetha ubungozi obunzulu be-thrombosis ye-vein and deep clots.
Ezinye iziphumo ziye zafumanisa ukuba ukuguquguquka kwe-Leiden ye-Factor kuthetha ukunyuka kweengcambu zokulahleka okuqhelekileyo , mhlawumbi ngenxa yamacandelo amancinci egazi avimbela ukuhamba kwezondlo kwi-placenta.
Unyango
Xa ukhulelwe, abanye oogqirha bakholelwa ekusebenziseni i- heparin kunye / okanye i-aspirin ye-dose ephantsi ukuphatha abafazi abane-Factor V Leiden geni kunye nembali yokulahleka kwezinto. Okwangoku, abaphandi bafunda le nyango ukuqinisekisa ukuba kunceda ngokwenene. Amaklinikhi amaninzi okuzala ancomela ukuba izigulana zithathe umntwana os aspirin ngexesha lotyando nje xa zineengxaki zokuqhawula.
Ubudlelwane kwiiMiscrareages
Abaphandi baqhubeka befunda ubunjani bobudlelwane phakathi kwe Factor V Leiden (kunye nezinye iintlobo ze- thrombophilias ). Iintlobo ezahlukeneyo zokuhlukumeza igazi zinezigaba ezahlukeneyo zobudlelwane nokuphuphuma kwesisu, kodwa i-Factor V Leiden yenye ye-thrombophilias yefa ebonakalayo inendima ekwenzeni ukulahleka kwemingcipheko (okanye ubuncipheko obuncipheko) kuba abafazi abanokuguqulwa kwamanani abanomlinganiselo ophezulu ukutshatyalaliswa kwamatyala ngaphandle kwabasetyhini abangenawo.
Uphando olufumanekayo lubonisa ukuba i-Factor V Leiden inokudlala indima kwiimfucuza ezenzeke emva kweiveki ezili-10 kodwa kungenakwenzeka ukuba zibe yinto ebangela ukulahleka kwamathambo okuqala.
Oogqirha abaninzi bavavanya i-Factor V Leiden njengenxalenye yempembelelo yokuphulukana nokuphuphuma komzimba kwaye bacebisa unyango kulabo bavavanya.
Imithombo:
I-Coulam, i-CB, i-RS Jeyendran, i-LA Fishel, no-R. Roussev, "Iinguqu ezininzi zeentsholongwane zentsholongwane kunokuba ziguqulwe ngokutshintshwa kwezinto eziphilayo ziyimingcipheko yokuphuphuma kwesisu." Ingxelo yeMerika ye-Immunology ngoMeyi 2006.
Foka, ZJ, AF Lambropoulos, H. Saravelos, GB Karas, A. Karavida, T. Agorastos, V. Zournatzi, PE Makris, J. Bontis, kunye no-A. Kotsis, "I-Factor V i-leiden kunye ne-prothrombin G20210A iinguqu, kodwa ayikho i-methylenetetrahydrofolate ukunciphisa i-C677T, zidibaniswa neengxowa-mpahla eziphindaphindiweyo. " Feb 2000.
UJivraj, S., R. Rai, J. Underwood, kunye noL. Regan, "Ukuguquka kweengcambu ze-Genetic phakathi kweembhangqwana eziphazamisayo." Ukuzaliswa kwabantu ngoMeyi 2006.
Reznikoff-Etievan, MF, V. Cayol, B. Carbonne, A. Robert, F. Coulet, kunye noJ. J. Milliez, "I-Factor V Leiden kunye ne-G20210A iinguqu ze-prothrombin zinguqu zengozi yokukhulelwa kwangaphambili." BJOG Dec 2001.
IYunivesithi yase-Illinois - Urbana / Champaign, "Izibonelelo zoMonde: I-Factor V Leiden." Ikhasi leMithombo yeHematology .
Walker, MC, SE Ferguson, kunye noVM Allen, "I-Heparin yabasetyhini abakhulelwe abane-thrombophili." I-Cochrane Library 21 Jan 2003.