Iingozi kunye Neempembelelo Zecala Zemithi Engenayo Inkunkuma
Ngaphambi kokuba uqale unyango kunye ne- gonadotropins - ngamanye amaxesha abizwa ngokuba yi-injection - ugqirha wakho kufuneka akuchazele iziphumo ezichaphazelekayo kunye neengozi zonyango. Unokuba uthatha i-gonadotropins kunye noClomid , ngokwabo, njengengxenye yomjikelezo we- IUI , okanye njengenxalenye yomjikelezo wonyango lwe- IVF .
I-Gonadotropins nayo isetyenziselwa abafazi ngokunikela amaqanda abo kunye neenkqubo zeqanda zokuqanda amaqanda .
Uninzi lweempembelelo ze-gonadotropin zincinci, kodwa kwiimeko ezinqabileyo, ezinye zinokuthi zizingcipheko kwaye zisongela ubomi.
Inqaku elibalulekileyo! Azikho zonke iziphumo ezichaphazelekayo nezingozi ezidweliswe ngezantsi. Ukuba unobungozi obubi kakhulu, iimpawu ezingavamile, okanye uxhalabele ngesizathu, qhagamshelana nogqirha wakho. Ingcaciso ekweli nqaku ayifaki indawo yokubonisana nochwepheshe bezonyango.
Ziziphi iiMediya ezibhekwa njengeGonadotropin?
I-Gonadotropins ziyingozi izidakamizwa ezinezityalo eziqukethe i-FSH, i- LH , okanye ukudibanisa ezimbini (ezibizwa ngokuthi i-gopaadotropins yabantu, okanye i-hMG). Kwakhona ziquka iHHM yeHHM , enezinto eziphilayo ezinjenge-LH.
Ezi ihommoni zithathwa nge-injection.
I-Gonadotropins inokuveliswa kwibhuyibrari usebenzisa i -DNA i-recombinant teknoloji ye-DNA , okanye iyakususwa ize ihlanjwe kumchamo we-postmenopausal okanye abakhulelweyo abakhulelweyo.
Amagama aseBrithani aseGonadotropini ayenziwe ngokusebenzisa i-DNA teknoloji ye-DNA i-Gonal-F (rFSH), i-Follistim (rFSH), iPuregon (rFSH), i-Luveris (rLH) kunye ne-Ovidrel (rHCG).
I-Bravelle, iMetrodin, kunye neFertinex ngamagama e-brand ye-FSH ekhishwe yi-FSH.
I-Novarel, i-Pregnyl, ne-Profasi zichithwe i-hCG.
Amagama eBrithani ye-gonadotropins yabantu abanjwe ngamanzi e-urine (inhlanganisela ye-FSH ne-LH) ibandakanya iHumegon, iMogog, iPergonal, Repronex kunye neMenopur.
Imiphumo emibi yeGonadotropins
Qaphela: Iipesenti ezingezantsi zibhekisela kuphando ngokuthelekisa iGonal-F - eyi-rFSH, eyenziwa kwibhabhi usebenzisa i-DNA teknoloji ye-recombinant, ne-urofollitropin, okanye i -FSH, ehlanjululwayo yi-FSH ekhutshweyo kumchamo weentombi ze-postmenopausal. IiRhafu zingahluka kancinane kwiziyobisi ukuya kwiziyobisi, kodwa iziphumo zonyango lwe-gonadotropin zifana ngokufanayo.
Iziphumo ezichaphazelekayo zegonadotropins ziquka:
- Intloko (rFSH: 22%, uFSH: 20.2%)
- I-nausea (rFSH: 13.6%, uFSH: 3.5%)
- Usulelo oluphezulu lweentsholongwane zokuphefumula (rFSH: 11.9%, uFSH: 7.9%)
- Ubumnene besisu (rFSH: 9.3%, uFSH: 12.3%)
- Igesi (i-RFSH: 6.8%, uFSH: 8.8%)
- Ukudibanisa kweSinus (i-rFSH: 5.1%, uFSH: 5.3%)
- Ukunyuka ngokubanzi (rFSH: 5.9%, uFSH: 6.1%)
- I-Mood swings (rFSH: 5.1%, uFSH: 2.6%)
- Acne (rFSH: 4.2%, uFSH: 2.6%)
- Ubumnene besisu (rFSH: 4.2%, uFSH: 6.1%)
- Ukuzuza ubunzima (rFSH: 3.6%, uFSH: 0.0%)
- Ukungahambi kahle kwepelvic (rFSH: 2.5%, uFSH: 6.1%)
- Ukuphuma ngegazi okanye ukungabonakali (rFSH: 2.5%, uFSH: 0.9%)
- Ukuvuthwa (rFSH: 2.5%, uFSH: 2.6%)
- Ubunzima bendawo yesifo, ubomvu (rFSH: 2.5%, uFSH: 0.9%)
- Utywala (i-RFSH: i-2.5%, uFSH: 0.0%)
Iingozi zeGonadotropins
I-Ovarian Hyperstimulation Syndrome (OHSS) : I-OHSS iyenzeka xa ii-ovari kunye nesisu zisuke zivuvule . Ukufika kwi-10 ukuya kwi-20% yabasetyhini baya kuhlakulela uhlobo olubi lwe-OHSS, oluya kuzinyulwa ngokwabo. Kubalulekile ukuvakalisa izibonakaliso ezinobungqina ugqirha wakho, ngoko unokukujonga ngokucophelela.
Ukuba unayo i- PCOS , usemngciphekweni ophezulu wokuphuhlisa i-OHSS.
I-OHSS ephezulu ivela ngaphantsi kwe-1% yezigulane. Xhalela ugqirha wakho ngokukhawuleza xa ufumana ukuhlanza, ubuhlungu obukhulu besisu okanye i-pelvic ubuhlungu, ukufumana isisindo esiphuthuma ngokukhawuleza, okanye ukuqhaqha okukhulu.
Ukukhulelwa kwamanani amaninzi : Ngokuxhomekeka kukuphi uhlolisiso olujonga ngalo, izinga lokuphindaphinda nge-gonadotropin unyango luvela kwi-2% ukuya kwi-30%, kunye ne-triplet ye-5% okanye ukukhulelwa okuphezulu.
Izilingo zonyango zifumene ukuba ukukhulelwa okuphindwe kabini kuya ku-12 kuya kwe-14% kwexesha xa usebenzisa i-rFSH okanye uFSH ngokulandelanayo. Ukubeka iliso ngononophelo kunye nokusebenzisa i-dose esebenzayo kakhulu kunokunciphisa umngcipheko.
Xa usebenzisa i-gonadotropini ngethuba le-IUI okanye yedwa, kunzima ukulawula umngcipheko weziphindaphindwa kunokuba zisetyenziswe ngexesha le-IVF. Ngexesha le-IVF, ugqirha wakho unako ukudlulisela enye imbungu.
Ukuba unomdla malunga nomngcipheko wokuphindaphinda, kwaye usebenzisa iinjirha njengenxalenye yomjikelezo we-IUI, unokufuna ukubuza ugqirha wakho malunga ne- mini-IVF .
Ama-cysts ama-ovari : Ama-cysts ama-ovari aqhelekileyo kunye ne-gonadotropins. Nge-rFSH, zenzeka malunga ne-15% yexesha, kwaye ngeFFS zivela malunga ne-29% yexesha.
Ngokuqhelekileyo, bazixazulula ngokwabo. Kwiimeko ezinqabileyo, kunokufuna ukungenelela okutyathwayo.
Ukusuleleka kwesayithi : Ukungabomvu nokunyamezela kuyinto eqhelekileyo, kodwa kwiimeko ezinqabileyo, indawo yokuxilongwa ingasenwasulelwa. Xhumana nogqirha wakho xa uqaphela kwisayithi yejoyilo ebandayo ebomvu, ukufudumala rhoqo, ukuvuvukala, ingxube, ukuvumba, okanye intlungu ebuhlungu. Kwakhona, ukuba ufumana umkhuhlane ngaphezu kwama-101, qhagamshelana nogqirha wakho.
I-Adnexal torsion (okanye i-ovarian twisting) : Kwiimeko ezinqabileyo (ngaphantsi kwe-2% yexesha), i-ovary ingakwazi ukuphazamisa, ukuphuka, okanye ukuphaphaza, okufuna ukungenelela kokungena. Oku kwenzeka ngenxa yokuba i-ovary iba nzima kwaye ikhulise ukusuka ekuvuseleleni.
Ukukhulelwa kwe-Ectopic : Umngcipheko wokukhulelwa kwe- ectopic ukwanda kancinci xa uthatha i-gonadotropins. Ukukhulelwa kwe-Ectopic kungasongela ubomi okanye kungadinga ukungenelela okutyathwayo.
Amacwecwe egazi : Unqabile kakhulu (4.2 kwi-1,000) kodwa unokusongela ubomi.
Ukwanda kwengozi yegazi ye-clot ayikho nje ngexesha lokunyanga, kodwa, ukuba ukhulelwe, uyaqhubeka ephakamileyo ngexesha lokukhulelwa.
Ukuba ufumana iimpawu zegazi elikhethiweyo - ukuvuvukala okanye intlungu emlenzeni omnye, ukufudumala kwindawo echaphazelekayo, utshintshe kumbala wesikhumba (obomvu, ubluhlaza okanye obala) - qha ga mshelana nodokotela wakho.
Ukuba uhlakulela iimpawu ze-pulmonary embolism - ukuqala ngokukhawuleza kokuphefumula, intlungu yesifuba esibuhlungu xa uzama ukuthatha umoya ophefumlelweyo okanye xa ukhwehlela, uziva unqabile okanye utyhafile, ujikeleza ngokukhawuleza, ukukhupha, ukukhwehlela igazi, ukuhlaselwa kwexesha elizayo - fumana uncedo lwezonyango ngokukhawuleza.
> Imithombo
Gonal-f (follitropin alfa for injection). Ulwazi lweziyobisi. http://www.accessdata.fda.gov/drugsatfda_docs/label/2004/20378scf015_gonal_lbl.pdf
Henriksson P, Westerlund E, Wallen H, Brandt L, Hovatta O, Ekbom A. "I-incidence of pulmonary and venous thromboembolism ekukhulelweni emva kokungenwa kwe-vitro fertilizer: i-cross-sectional study." 2013 Jan 15; 346: e8632. i-doi: 10.1136 / bmj.e8632. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3546085/
Iimiphumo ezingezantsi zeGonadotropins: Iphepha leNgcaciso loMonde. Umbutho waseMelika weMithi yokuzala.