Kutheni abanye abaNzululwazi bangabazeki ukuba uMbutho ukhona
Ukugxila kwengqalelo kuye kwafakwa kwinto ebizwa ngokuba yi-MTHFR ukuguquka kwezakhi zofuzo kunye nemibutho yayo eneempawu zezempilo ezingavamile, ezinye zazo zixhaswe ngokuqinile kwaye ezinye zazo ziyizicatshulwa.
Kwiminyaka yakutshanje, inzululwazi ezincinane zicebise ukuba ukuguqulwa komzimba kungacacisa kakuhle ukuba kutheni abafazi abathile bahlaselwa ngamathambo .
Ngelixa le ngcamango ingekho ngokugqibeleleyo, ibangela ukuba i-roletics ikwazi ukudlala kwiimfucuza ezingabonakaliyo, ukuba inxalenye kuphela.
Ukuchaza ukuguquguquka kweMTHFR
Ukuguqulwa kwe-MTHFR yinto engenakonakala kwimeko yomntu yokwenza i-genetic coding ephazamisa amandla omzimba wokuvelisa i-enzyme ye-MTHFR. I-enzyme ye-MTHFR, kwakhona, yikhemikhali eyenziwa ngumzimba ukuba idibanise kakuhle i- folic acid (i-vitamin B9) .
Ukungaphumeleli kwe-enzyme kunokubangela ukuba kubekho iingxaki. Eyona nto inzima kakhulu ilindeleke ukuba ivele kubantu abazuze iinguquko ze-MTHFR kubazali bobabini (into ebizwa ngokuba yi-homozygosity), ngelixa abo bafumana ilifa elilodwa (i-heterozygosity) banokuba neengxaki ezimbalwa, ukuba zikhona. Ukuba ne-MTHFR mutation ayithethi ukuba uya kufumana isifo esithile; kwandisa nje ingozi yakho jikelele.
Ezinye zeengxaki zempilo ezixhomekeke kwiinguqu zeMTHFR ziquka:
- I-Homocystinuria, i-disorder apho umzimba ungakwazi ukwenza inkqubo ye-homocysteine, ngokusoloko ikhokelela kwiingxaki zamehlo, ukugqithiswa kwegazi okungavamile, ukungabikho kwegazi kunye neengxaki zokuqonda
- I-Anencephaly , isiciko sokuzalwa esichazwe ngamacandelo angekho okanye angenakuqulunqwa ngokupheleleyo kwengqondo okanye ingqayi
- U-Spina bifida, ukubunjwa okungaphelelanga kwethambo ejikeleze intambo yomthambo
- Ukulahlekelwa kweendlebe ezihlobene nokuguga
Ezinye izifundo zidibanise ukuguqulwa kwe-MTHFR kwisifo senhliziyo, isifo, ingozi yegazi, i- preeclampsia (uxinzelelo oluphezulu lwegazi ngexesha lokukhulelwa), i-glaucoma, izifo zengqondo, kunye neentlobo ezithile zomhlaza. Uninzi lwezi zifundo luxutywe kakhulu. kunye nemibutho efunyenwe kwezinye kodwa kungekhona kwabanye.
Zonke zixelelwe, ukuguqulwa kohlobo lwe-MTHFR kuqhelekileyo, kunye nesantsi-sithuba se-United States sinokubakho ubuncinane be-heterozygous ukuguqulwa.
I-MTHFR kunye noKhenketho lokuThathatshana
Ngenxa yokuba ubungqina obunjalo buxhaswa ngokusisigxina, zininzi izazinzulu eziye zenza umngeni umbono wokuthi ukulahleka kwamathambo kunye nokuguqulwa kweMTHFR kunxulumene ngandlela-thile. Abo baxhasa i-hypothesis benza njalo ngokusekelwe kwimeko yeziganeko zokuphuphuma kwesisu phakathi kwabasetyhini abaneentlobo ezithile ezibizwa ngokuba yi-MTHFR C677T.
Isitshixo kumbango yendima eyenziwa ngu- homocysteine ukuba idlale. I-Homocysteine i-amino acid eveliswa ngumzimba eyanceda kwi-metabolism ye-vithamini B. Ngaphambi kokuguquguquka kwe-C677T, i-homocysteine ayikwazi ukuphinda iphinde ibuye iphinde iphinde iqokelele kwigazi. Xa oko kwenzeka, kunokukhokelela kwisimo sokuvuvukala esibizwa ngokuba yi-homocysteinemia eyaziwayo yengozi ye-coronary artery disease.
Abo baxhasa le ngqungquthela bacebise ukuba i-homocysteinemia inokubangela ukubunjwa kwee-blood clots ezincinci ezithintela ukuhamba kwezondlo kwi-placenta, ngokuqinisekileyo zilambile umntwana kwaye zidale ukukhipha isisu . Ingqungquthela ephikisanayo kwaye enye ingekho ubungqina obunzima.
Xa kuthethwa oko, abaninzi abafazi abanokuphuphuma kwesisu ngokuphindaphindiweyo baya kuvavanya kakuhle ngenxa yokuguqulwa kweMTHFR. Ngaloo ndlela, abanye oogqirha baye bakuvumela ukusetyenziswa kwezidakamizwa ezichasayo ezifana ne- heparin kunye ne-aspirin ye-dose ephantsi ukunciphisa umngcipheko wee-clots zegazi. Abanye batusa amanqanaba aphezulu e-aclic acid kunye nezinye ii-vitamini ze-B, ekukholelwa ukuba oko kunokwenzela i-homocysteine ithagethi kunye nendlela eya kukhishwa ngayo emzimbeni.
Nangona kungekho bungqina bokuba nawaphi na amanyathelo aya kunciphisa umngcipheko wokuphuphuma kwesisu, kukho ubungqina obuncinane bokubonisa ukuba uya kwenza nayiphi na ingozi.
Igama elivela kwi-Verywell
Ingxabano iyaqhubeka icutha ngokumalunga nokuguquka kwe-MTHFR ekukhulelweni, isiluleko sika-2013 esivela kwi-American College of Obstetricians kunye ne-Gynecologist yathi ubungqina obukhoyo malunga nomcimbi "bukhawulelwe" okanye "buhambelani" kwaye bacebise ngokusebenzisa i-MTHFR genetic ukuhlalutya okanye ukuzila ukutya kwe-homocysteine njengenxalenye yesifundo sokufunda ngaphambi kokubeleka .
> Imithombo:
> Ikholeji yase-American College of Obstetricians and Gynecologists. "I-ACOG Yenza i-Bulletin yeNombolo 138: I-thrombophili ezuzwayo ngokukhulelwa." Gstecol Obstet. 2013; 122 (3): 706-17. INGXELO: 10.1097 / 01.AOG.0000433981.36184.4e.
> Chen, M .; Yang, X; kunye noLu, M. "I-Methylenetetrahydrofolate iyanciphisa i-polymorphisms yomzimba kunye nokulahleka okuphindaphindiweyo e-China: ukuphononongwa ngokuchanekileyo kunye nokuhlaziywa kwemeta." I-Arch Gynecol Obstet . 2016 Feb; 293 (2): 283-90. INGXELO: 10.1007 / s00404-015-3894-8.