Amanqanaba aphakanyisiweyo we-Homocysteine kunye neengxaki zokukhulelwa
Ukuba unamaqhekeza aphindaphindiweyo, ugqirha wakho unokuthi ukhuthaze ukujonga izinga le-homocysteine egazini lakho. Yintoni kanye i-homocysteine? I-homocysteine inxulumene njani nokukhulelwa kwesisu kunye nezinye iingxaki zokukhulelwa?
Yintoni i-Homocysteine?
I-Homocysteine luhlobo lwe-amino acid efunyanwa ngokwemvelo emzimbeni. Kwinqanaba eliqhelekileyo, akuyona into eyingozi, kodwa amanqanaba aphakamileyo afumaneka adibene nokuphuphuma kwesisu kunye nesifo senhliziyo.
Inqanaba eliphezulu le-Homocysteine
Iqondo eliphakamileyo le-homocysteine egazini liphumela kwimeko ebizwa ngokuba yi-hypercoagulability. Igama elithi coagulation libhekisela kwi-clotting yegazi, kwaye i-hypercoagulability ithetha ukuba i-blood clots elula kangangoko kunokwenzeka.
Xa oku kwenzeka emitanjeni yegazi, njengemibhobho ye-coronary, inokuba negalelo kwiimvumba ezithintela imithana yegazi eyenza isifo se-coronary disease.
Ngokukhulelwa, kucinga ukuba la macala amancinci egazi angakwazi ukuvimbela imithwalo yegazi kwi-placenta, ekhokelela ekuphumuleni.
I-Homocysteine ephezulu kunye noKhathatyathwa koLuntu
I-homocysteine ephakanyisiweyo ayisabonakali ukuba ibangele ukuphuphuma kwesisu, kodwa kukho ezinye iimeko eziqhelekileyo kunye nezinye iimeko eziyaziwayo ukukhokelela ekulahlekeni kwamathambo. Enye imeko, ebizwa ngokuba yi- antiphospholipid syndrome , inokubangela ukuphuphuma kwesisu kunye nesifo senhliziyo ngendlela efanayo.
Okunye ukukhulelwa kwengxaki
I-homocysteine ephakamileyo yinto engumngcipheko oqinisekisiweyo kwezinye iingxaki zokukhulelwa kuquka:
- Ukunciphisa ukuzala
- Iziphene zokuphuhliswa kwabazali, ezifana neziphene ze-neural tube ezifana ne- anencephaly
- Preeclampsia
- Ukukhawuleza kokukhula kwe-intrauterine
Njengoko kuhamba ngesisu, ubungqina bungahambelani nokuba amazinga aphezulu ase-homocysteine enza ezinye iingxaki zokukhulelwa ezifana:
- Ukuphazamiseka kwePlacental
- Down syndrome
Ukuphikisana Xa kuhlolisiswa Ukuzila ukutya kwe-Plasma Homocysteine (tHcy) ekukhulelweni
Ukuba ugqirha wakho uhlola i-homocysteine level, kubalulekile ukwazi ukuba amazinga aqhelekileyo angama homocysteine ngexesha lokukhulelwa. Ngamanye amagama, inqanaba elithatyathwe ngenye ixesha ngelo xesha, akunjalo, limela ukuba amanqanaba akho aninzi kangakanani ixesha. Kukho iinkalo ezininzi zokutya kunye neendlela zokuphila ezikhokelela ekutshintsheni kwemini kwinqanaba. Ukongezelela, utshintsho kwimiqulu yegazi oluhlobene nokukhulelwa kunye nenani leenguqulelo ze-hormonal lungabangela amazinga ngexesha lokukhulelwa okungathi imele ukuba amazinga akho ayenjani ukuba awukhulelwe.
I-Metabolism ne-Genetics yamazinga akwa-Homocysteine
Ukuba unamazinga aphezulu e-homocysteine, i-genetics yakho ingabangela.
Abantu abahlukileyo kwi- gene ye- MTHFR , ngokukodwa ukuhlukahluka kwe-C677T, banakho amathuba okuba namazinga aphezulu ase-homocysteine. Kwaye ezinye iifundo zifumene ukulungiswa phakathi kweMTHFR gene variants and increase risk loss. Inkolelo ekhokelayo emva kobudlelwane kukuba amazinga aphezulu ase-homocysteine kubantu abane-genetic variants are a risk of carriage.
Olunye ugqirha luvavanya i-MTHFR i-gene variants njengenxalenye yovavanyo lokuphuphuma kwexesha lokuphuphuma komzimba .
Abanye bacinga ukuba kubaluleke kakhulu ukuvavanya i-homocysteine kuba kungekhona wonke umntu onokuhluka kwezinto ze-MTHFR eza kuba namazinga aphezulu e-amino acid.
Izizathu
Iinguqu zegciwane ze-MTHFR azikho kuphela imbangela ye-homocysteine ephakamileyo.
Iinguqu zegciwane ze-MTHFR azikho kuphela imbangela ye-homocysteine ephakamileyo. Umzimba wakho usebenzise izondlo ze- folic acid , i-vitamin B6 kunye ne-vithamini B12 ukuxilisa, okanye ukusebenzisa i-homocysteine. Abantu abangenayo kulawo mavithamini banokuba namazinga aphezulu a-homocysteine.
Iimeko ezahlukeneyo zempilo kunye neyeza zi nodibanisa namazinga aphezulu ase-homocysteine.
Ezinye zezoMngcipheko zeMpilo
Nangona indima ecacileyo ingaziwa, amazinga ase-homocysteine aphakanyisiwe afunyanwe kwi-atherosclerosis, ukuhlaselwa yintliziyo, ukuphazamiseka kwengqondo, ukugula komzimba, isifo seParkinson, isifo se-sclerosis, kunye nokuhluthwa.
Kucingelwa ukuba amazinga aphakanyisiweyo e-homocysteine egazini anokuba nefuthe ngqo kwi-system ye-vascular and nervous system.
UkuPhatha i-Homocysteine ephakamileyo kwizinto ezingaqhelekanga
Akukho ziphakamiso ezisesikweni ukujonga amanqanaba angama-homocysteine kwabasetyhini abaphumayo ngokusweleka komzimba, kwaye akukho zikhokelo zonyango ezicetyiswayo emhlabeni wonke zokuphatha amanqanaba aphezulu ase-homocysteine kwabasetyhini abafunyanwa ukuba nabo.
Noko ke, abanye oogqirha bavavanya i-homocysteine (okanye i-MTHFR gene variants) kubasetyhini abanokulahlekelwa kokukhulelwa okuphindaphindiweyo kwaye batusa unyango nangokuba kungekho ziphakamiso ezisesikweni.
Iingcebiso eziqhelekileyo kubasetyhini abanamazinga aphezulu ase-homocysteine kukuthatha amanani aphezulu e-folic acid kunye ne-vithamini B ukuphucula umzimba we-homocysteine. Yenza njalo kunye neziphakamiso zegqirha zakho, nangona kunjalo, njengamazinga aphakamileyo ala mavithamini asenokungabangela kuphela iziphumo zecala kodwa angaphazamisa ukuxutywa kwamanye amavithamini. Kwalabo abane-genetic variants of MTHFR, i-folic acid eyongeziweyo ayifumananga ukunciphisa umngcipheko wokukhulelwa kwesisu.
Oogqirha abambalwa banokuncoma unyango olwachasayo, olufana ne- heparin okanye i-aspirin ye-dose ephantsi , ukwenzela ukuthintela ama-clots egazi ekuveleni ngexesha lokukhulelwa, kodwa lo mkhuba awukho umgangatho.
Ngombulelo, kukho iinjongo eziqhubekayo zijonga iimpendulo zemibuzo emibini malunga naluphi indima ephakamileyo yamanqanaba e-homocysteine ekukhulelwe kunye nendlela efanelekileyo yokuphatha ngayo ukuba ngaba kukho.
Imithombo:
Ansari, R., Mahta, A., Mallack, E., noJo Luo. I-Hyperhomocysteinemia kunye neengxaki ze-Neurological: Uhlolo. Umbhalo we-Clinical Neurology . 2014. 10 (4): 281-8.
Hekmatdoost, A., Vahid, F., Yari, Z., Sadeghi, M., Eini-Zinab, J., Lakpour, N., no-S. Arefi. I-Methyltetrahydrofolate ne-Folic Acid Supplementation kwi-Idiopathic Ukutshatyalaliswa okuqhelekileyo kunye nokuhlonipha iMethylenetetrahydrofolate I-C677T kunye ne-A1298C I-Polymorphisms: Uvavanyo oluLungeleleneyo oluLungisiweyo. PLoS One . 2015. 10 (12): e0143569.
ULevin, B., no-E. Varga. I-MTHFR: Ukubhekiselele kwiDilemmas ye-Genetic Counseling Dilemmas esebenzisa iiNcwadi ezisekelwe kwiingxelo. I-Journal ye-Countic Counseling . 2016. 25 (5): 901-11.
Puri, M., Kaur, L., Walia, G., Mukhopadhhyay, R., Sachdeva, M., Triveldi, S., Ghosh, P., kunye noK. Saraswathy. I-MTHFR C677T I-polymorphism, i-Folate, i-Vitamin B12 kunye ne-Homocysteine kwiNtsholongwane yokuLawula okuKhuselekileyo: UkuFundwa kweCandelo lokuLawula phakathi kwabantwana baseNorth Indian. Umbhalo weMithi yePerinatal . 2013. 41 (5): 549-54.
Murphy, M., noJerandez-Ballart. Homocysteine ekukhulelweni. Kuthuthukile kwiKhemistri yeKliniki . 2011. 53: 105-37.