Khangela ngokugqithiseleyo le ngongoma
Kungenzeka ukuba uvile nge progesterone, ingakumbi ukuba uye wafumana ukulahleka kwezinto eziphambeneyo. Iprogesterone yi-hormone ehambelana nokukhulelwa kunye nomjikelezo wesini.
Amanqanaba okunyuswa kweprogesterone nyanga zonke emva kokuvuthwa, ukulungiselela ubhedu lwesisu ngokukhulelwa. Kwimijikelezo yokungena kwemizi engazange ikhulelwe, amanqanaba e-progesterone akhuphuka emva kokuvuthwa kwaye awele ngaphambi kokuba umfazi afike kwimihla. Xa ukhulelwe, inqanaba leprogesterone kufuneka lihlale liphakanyisiwe. Ama-ovari akhiqiza ininzi yeprogesterone ngokubanzi kwekota yokuqala, kodwa ekugqibeleni, i-placenta ithatha ukuveliswa kwehommone malunga neveki yeshumi yokukhulelwa.
Ngenxa yokuba i-progesterone inendima ekulondolozeni i-uterine bining, abanye abaphandi baye bathi i-progesterone encinci ngaphambi kokuba ukukhulelwa kwesisu kungaba nendima ekubangela ukuphuphuma kwesisu . Kodwa ukuba ukuxhaswa kweprogesterone ngokwenene kuvimbela ukuphuphuma kwesisu kungumcimbi weengxoxo.
Ubume bangoku
Okwangoku, akukho mibutho yezokwelapha incoma ukuxhaswa kweprogesterone kubasetyhini abaneengxaki zesigaba okanye i-miscarriages ephindaphindiweyo, ngaphandle kwabasetyhini abasebenzisa ubuchwepheshe bokuzala ezifana ne-IVF.
Akukho zifundo zenzululwazi zifumene ubungqina obuchanekileyo bokuthi i-progesterone isongezelelo sokuthintela ukungahambi kakuhle kwabesetyhini abangasebenzisi iindlela zokuvelisa izinto zokufakelwa. Uninzi lwezifundo azifumani nantlukwano kwimilinganiselo yokuphuphuma kwesisu xa kuthelekiswa nabasetyhini abathathe iindululo ze-progesterone kubafazi abangenalo.
Uphando oluthile lufumene ubungqina bokuthi ukuthatha izongezelo zeprogesterone kunokuba luncedo kubasetyhini abaye bahlaselwa ngamathambo, kodwa ngoku kwangoku amanani awancinci ukuthetha ukuba ngaba iziphumo zifunyenwe. Uphando olongezelelweyo lufanele lwenziwa phambi kokuba iingcali ziyakwazi ukuba izibonelelo ziyanceda.
Ziziphi zonke iNgxabano malunga?
I-progesterone ephantsi ekukhulelweni ngokuqinisekileyo inxulumene nokuphuphuma kwesisu, kodwa isizathu sokuba kutheni. Ngakolunye uhlangothi, amanqanaba aphantsi kakhulu angabangela ukuba i-stersion ifsus isingakulungele ukuxhasa ukukhulelwa, mhlawumbi ngenxa yokuba ii-ovari zineengxaki zokuvelisa i-progesterone eyaneleyo ngesizathu esithile.
Ngakolunye uhlangothi, oogqirha abaninzi bakholelwa ukuba i-progesterone ephantsi ithetha nje ukuba ukutshatyalaliswa kwesisu kufikelele kwezinye izizathu. Ngale ndlela yokucinga, amanqanaba aphantsi ngumqondiso wokuqala wokuba umzimba ulungele ukukhulelwa ukukhulelwa okwehlulekile kwezinye izizathu, ezifana ne-chromosomal engafanelekanga kwintsana ekhulayo, kunye ne-progesterone supplementation ayiyinto engelusizo.
Okwangoku, akukho namnye owaziyo impendulo echanekileyo, kwaye isihloko sifana nomba wengxoxo enentliziyo.
Iinkonzo
Oogqirha ngabanye banokuba namava eokliniki abona bafazi beza kuhlaselwa ngokungaqhelekanga kwaye emva koko bakhulelwe ngokuphumelelayo emva kokuxhaswa kweprogesterone, kwaye ke banokuba ngabazalwana abanamandla kwiingcamango ukuba uyasebenza.
Abanye oogqirha basebenzisa i-progesterone zongezelelo kuphela kwabasetyhini abaye bavavanywa njengokuba babe ne-progesterone ephantsi. Oogqirha abasebenzisa le ndlela banokuvakalelwa ukuba izifundo ezikhoyo azizange zihlolwe ngokwaneleyo izigulane, njengokuba uphando lweprogesterone njengamanje alukwahluli abafazi abanamaqondo aphantsi e-progesterone ukusuka kwabesetyhini abaye bafumana ukulahleka kwezinto ngenxa yezizathu . Kwakhona, banokufumana amava e-kliniki ekuboneni abafazi abanamaqondo aphantsi aseprogesterone baphela baphathe umntwana ukuya kwikota emva kokuxhaswa, ngoko bakholelwa ukuba kusebenza.
Ngenxa yokuba umzimba uvelisa i-progesterone ngexesha lokukhulelwa nangona kunjalo, kwaye ezininzi iimveliso ezithengiswayo kwiimarike zinokwenziwa kwamakhemikhali afana neprogesterone eyenziwa emzimbeni, amaninzi amaninzi afaka ukuba ukuxhaswa kwabasetyhini abanamaqondo aphantsi akunakwenzeka ukwenza nantoni na nokuba akuncedi. Benza isigqibo sokuhamba nefilosofi yokuba ukuba i-progesterone ayikwazi ukulimaza kwaye inokukunceda, banokuyilungisa.
Umxhasi
Oogqirha abangaqulunqanga izongezelelo ze-progesterone banokunganqikazi ukuba banikeze nayiphi na isilwanyana ngaphandle kokubonisa ukuba kusebenza-kwaye banomhlaba omhle wokuhlala. Ngama-1950 ukuya kuma-1970, oogqirha banqamle isilwanyana esibizwa ngokuba ngu-DES kubafazi abakhulelweyo benengcamango yokuba iya kuthintela ukukhulelwa kwesisu-eso sigqirha sagqithiselwa ukuba sibangele ubuninzi bokuzala okungabonakali kwabantwana.
Nangona amaninzi amagqirha aziva ukuba i-progesterone supplementation mhlawumbi ikhuselekile, akunakwenzeka ukusho ukuba kwiminyaka eyi-10 okanye engama-20 isifundo singabonakalisa ingozi yokusebenzisa isongezelelo seprogesterone ngexesha lokukhulelwa. Oogqirha banokulinda izikhokelo ezicacileyo ngaphambi kokuqhubeka.
Oogqirha banokuvakalelwa kukuba, de u bungqina benzululwazi bubonisa inzuzo ecacileyo, kunokwenzeka ukuba i-progesterone ephantsi ithetha nje ukusilela kwesisu, kwaye ukucacisa i-progesterone xa ukukhulelwa sele kulungiselelwe ukuphazamiseka kunokulibazisa ukuqala kwegazi.
Ekuxubungeni ubungqina obungqina bokuthi u-progesterone ubonakala usebenza, oogqirha abanqwenela ukuxhaswa kweprogesterone bangabhekisela kwingcamango yokuba abafazi abanesifo sengqondo esipheleleyo sithatha inqanaba eliphezulu kwimpumelelo ngaphandle kwonyango-ngoko kwimeko engalawulwayo, kunokwenzeka ukuba ibhinqa elongezelelweyo neprogesterone laliza kuba nokukhulelwa okuphumelelayo nangaphandle kwonyango.
Apho ibeka khona
Oogqirha abanemibono eyahlukileyo kwiprogesterone, ngoko uya kufumana abathile abanikezelayo kuwo wonke umfazi oye wahlaselwa ngamathambo angaphindiweyo, abanye abayalela kuphela kubafazi abanamaqondo aphantsi aseprogesterone, kunye nabanye abangeke basebenzise izongezelelo ze-progesterone (ngaphandle kwezigulane usebenzisa iindlela zokuvelisa izakhi).
Kuyinyani ukuba akukho mntu uyazi ukuba ngaba i-progesterone isongezelelo yokusebenza, kwaye akukho nxalenye yeprogesterone eya kwenza umehluko kwisiphumo esiphezulu sabasetyhini abanesisu ngenxa yokungaqheleki kwe-chromosomal okanye izizathu ezifanayo.
Iprogesterone izongezelo mhlawumbi zikhuselekile. Akukho mntu ufumene ubungqina bokuba bangabangela ingozi. Ukuba ugqirha wakho ekucebisa ukuba usebenzise i-progesterone, qiniseka ukuxoxa ngezinto ezinokubangela ukuba uxhalabele kwaye unokubamba iingqalelo zombini phambi kokuba wenze isigqibo sakho. Ngokufanayo, ukuba ugqirha wakho akayi kunika umyalelo we-progesterone, qiniseka ukuba ucinga ngezizathu ezikuloo ndlela ngaphambi kokuba wenze isigqibo malunga nenkathalo yakho yesikhathi esizayo.
> Imithombo:
> Iixhala malunga nokuThuthukiswa koThutho lwabantwana. Umama waseMelika wokukhulelwa. http://americanpregnancy.org/pregnancy-complications/early-fetal-velopment/.
> I-Daya S. I-Luteal Inkxaso: IiProgestogens zokukhusela ukukhulelwa. Maturitas . 2009; 65. i-doi: 10.1016 / j.maturitas.2009.09.012.
> Haas DM, uRamsey PS. Progestogen yokukhusela ukutshatyalaliswa komtshato. I-Cochrane Database yeeNkcazo eziPhezulu 2013, Inkcazo 10. Ubugcisa. Hayi: CD003511. INGXELO: 10.1002 / 14651858.CD003511.pub3.
> I-Progesterone Supplementation Ngethuba leSigaba seLuteal nakwixesha lokukhulelwa kwangaphambili kwi-Treatment of Infertility: i-Bulletin yezemfundo. Ukhuseleko kunye nobuthathaka . 2008; 90 (5). i-doi: 10.1016 / j.fertnstert.2008.08.064.
> Wahabi HA, Fayed AA, Esmaeil SA, Al Zeidan RA. I-Progestogen yokuPhatha ukuThatyalaliswa kweNdlu. I-Cochrane Database yeeNkqubo eziPhezulu zoViwo lweeNkcazo zika-2011 Inombolo: CD005943. INGXELO: 10.1002 / 14651858.CD005943.pub4.