Ukuphikisana kweZenzalo malunga neC cells kunye nokungafani
Kungakhathaliseki ukuba iiseli zombulali zendalo (okanye iiseli ze-NK) zingabangela ukuba ukuphuma kwesisu kuxoxwa ngokubanzi phakathi kweengcali zenzalo . Yintoni esiyayazi malunga nobukho bee-N cells kulabo abanezintlu zangaphantsi, kwaye ziphi iingozi kunye neenzuzo zonyango olululo?
Ziziphi iiCells Killer Cells (NK Cells)?
Iiseli zokubulala zendalo (iiseli ze-NK) zihlobo lwe-lymphocyte, enye yeentlobo zeeseli ezimhlophe zegazi kwi-system immune system.
Ezi iiseli "zilwela," ezijongene nokuphelisa amaseli anentsholongwane yentsholongwane kunye neeseli zomhlaza ezisuka emizimbeni yethu.
Nguwuphi umSebenzi weZityalo eziMzimba eziMzimba kwiNkqubo yoVukeleko?
Amajoni ethu omzimba aphuhliweyo abe ngamacandelo amabini asisiseko. "I-immune system system" okanye "i-immune-system immune system" isebenza ngendlela engacacile, ihlasele nayiphi na into engaphandle engena emzimbeni wethu kungakhathaliseki ukuba yintoni. Ngokwahlukileyo, isimiso somzimba sokuzikhusela sisisigxina se-immune system esichaza abahlaseli abathile. Le nxalenye ye-immune system inoxanduva lokukhumbuza umonakalisi kwaye ilungele ukuba libuyele. Ngaloo ndlela, idlala indima ebalulekileyo ekugonyeni oye wafumana kwiintsholongwane eziqhelekileyo.
Njengengxenye ye-immune system (okanye engekho). Iiseli ze-NK zinemisebenzi ebalulekileyo:
- Iiseli ze-NK zingabopha nge-intruder, ukukhulula i-granules enetyhefu okanye iqhube i-cell okanye ibangela ukuba ife
- Iiseli ze-NK zinokusebenza njengama-immunoregulators, ukulawula ezinye iinjongo ze-immune system ngokuvelisa i-cytokines
Yintoni esiyayazi malunga neeCells Killer Cells (NK cells) kunye nokutshatyalaliswa?
Kukho ubungqina obuninzi bokuthi iiseli zokubulala zendalo ziphakanyisiwe kwi-bloodsteam (kunye nesisu) sabasetyhini abaneemfucuza eziphindaphindiweyo, kodwa kungekho ubungqina obuninzi bokuthi i-cells ze-NK ezona zibangele ukulahleka.
Nangona igama elingaqhelekanga lokulila, iiseli zombulali zendalo akuyona into embi ukuba nayo. Iiseli ze-NK zidlala indima ebalulekileyo ekusebenzeni kwe-immune system. Bancedisa umzimba ukulwa nezicubu kunye nokutshabalalisa amaseli anentsholongwane yi-virus kunye nomhlaza weseli.
Ngenxa yamanqanaba e-NK ephakamileyo kwabasetyhini abaneemfucuza eziphindaphindiweyo , abanye abaphandi bakholelwa ukuba iiseli zeN NK nazo zijongene nomzimba wesifazane ophelisa ukukhulelwa. Nangona kunjalo, kukho ezinye izizathu zokuba iiseli ze-NK zinokuphakanyiswa.
I-Case For NK Iiselingi ekuHlalweni kweNdlu
Kunzima ukuphikisana ukuba i-cells ze-NK ziphakanyisiwe kwabasetyhini abaye bahlaselwa ngamathambo aphindaphindiweyo ukususela ekuphandeni kwezifundo ezininzi baye bafumanisa ukuba oku kuyinyaniso. Abaphandi baye bacebisa ukuba ii-cell eziphezulu ze-NK zingasemva kweyona enye yesithathu yazo zonke izinto ezingabonakali.
Iingcali zenzululwazi zenze iindlela ezimbalwa apho iiseli ze-NK ezinokuphakama zikwazi ukuphelisa ukukhulelwa okukhuselekileyo , ngokuqhelekileyo ukukhuthaza ingcamango yokuba isistim somzimba esasiphazamiseka sisenza ukuba iiseli zihlasele ukukhulelwa. Ubuncinane isifundo esisodwa sifumene ubungqina bokuba iiseli ze-NK kwiiseli zokuhlaselwa kwamaseli ukusuka ekukhulelweni kwiimeko zokungahambi kakuhle, nangona akucaci ukuba zeziphumo zithini.
Abanye abaphandi baye bajonga i-chromosomes yokukhulelwa okungaxakaliyo ukuqinisekisa ukuba i-N cells zaphakanyiswa ngenxa yempendulo yomzimba kwimeko yokukhulelwa okungavamile . Abaphandi bafumanisa ukuba abafazi abaneenjini ze-NK eziphakamileyo banokuthi bangakwazi ukuphazamisa umntwana oqhelekileyo ngokukhulelwa kwabo ngokuzayo.
Ukuba iinyaniso ze-NK eziphakamileyo zikhupha ukukhulelwa okukhuselekileyo, ukunciphisa ama-NK aphezulu kufuneka akhokele kumngcipheko wokuncipha. Izifundo zijonge ukusetyenziswa kwee-corticosteroids (ezifana ne-prednisolone) kunye ne-IV immunoglobulins (IV gammaglobulin) kulabo abanembali yokuphuphuma kwesisu.
Izifundo ezimbalwa ziye zafumanisa ukuba ezi zonyango, ngakumbi i-IV immunoglobulins zinokunyusa ithuba lokuba abathathi-nxaxheba baya kuthwala ukukhulelwa kwabo emva kwexesha. Abaphandi bancoma ukuba kwenziwe olunye uphando ukuze kuqondwe ingozi kunye neenzuzo zonyango.
Icala elichasene neC cells kwi-Maritime
Kukho ininzi yeenkcazelo ezongezelelweyo malunga nokufunyanwa kwamaseli e-NK aphezulu kwabasetyhini abaneemfucuza eziphindaphindiweyo.
Kukho ubungqina bokuthi uxinzelelo lunokubangela ukuguquka kwiiN cells. Uphando olususela ngo-2006 lufumanise ukuba abafazi abanamaqhekeza aphindaphindiweyo abaye bakwazi ukuphakamisa iiseli ze-NK kwigazi lokuqala lokuqala-kodwa ke kwigazi lesibini lithatha imizuzu engama-20 kamva, abanakubonisa ukuba akukho manqanaba e-NK xa kuthelekiswa nabasetyhini abangenanto ukukhulelwa komzimba. Abaphandi bacacisa ukuba kwakukho ithuba lokuba abanye abafazi bafuna ukuba nesistim somzimba esasabela ngokukhawuleza ukuxinezeleka, esinokubambisana nenye enye yophando ebonisa ukudibanisa phakathi kokuxinzezeleka nokukhulelwa komzimba .
Ngokuqinisekileyo kunokwenzeka nokuba iiseli ze-NK eziphakamileyo ukuba "zingabangela" ingozi yokukhulelwa komzimba, kodwa ukuba zombini iiseri ze-NK kunye nokulahleka kwamathambo okuphindaphindiweyo kuxhomekeke kwisimo esifanelekileyo sokuzikhusela komzimba esingakhokelela kuzo zombini. Uphando olunye lujonge ukhonkco phakathi kweeseli ze-NK, ukukhulelwa kwesisu, nesifo se-thyroid.
I-Cell Death Killer ehambelanayo neeyeza zokwahlukana
Kukho uphando oluninzi oluye lwenziwa ukuba luqhutywe luhlalutya ubukho beeseli ze-NK eziphakamileyo phakathi kwalabo abanesifo sengqondo esiphindayo, kwaye naluphina unyango lujongwa njengoluvavanyo ngeli xesha. Nangona i-IV immunoglobulin sele idibaniswe nokunciphisa i-miscarriages ephindaphindiweyo kwaye inikwe izithupha, kukho naluphi na olu lwalu unyango. Ucwaningo lufumene ukuba i-dose ephezulu ye-corticosteroids ingathintela kakubi ukukhulelwa kwangaphambili. Naluphina unyango oluthathwa njengolu vavanyo lufanele lucingwe ngokucokisekileyo malunga neentlobo ezifanelekileyo kunye nomngcipheko wonyango.
Ngaphandle kwezihloko zentloko, akukho nhlangano yezokwelapha incoma uvavanyo kunye nokunyanga iiseri ze-NK kubasetyhini abaneemfucuza eziphindaphindiweyo. Kukho uphando oluninzi olufuneka luyenziwe ngaphambi kokuba nabani na onokuyincoma i-steroids okanye abaxinzezeli-mzimba njengempilo yokuphulukana nokukhulelwa komzimba. Nayiphi na unyango lwee-NK ezisezantsi zimele zijongwe njengoluvavanyo kweli nqanaba. Ngethuba elifanayo ukuba ezi zonyango zingenakunceda, zonke ziphethe imiphumo emibi efuna ukulinganiswa nayiphi na inzuzo.
Ngaphantsi kwi-NK Cell Treatment Related kunye neMiscrarections ephindaphindiweyo
Kukho izikhewu ezininzi ekuqondeni ukuba iiseli ze-NK zichaphazela njani ukukhulelwa .
Ukuba unesisu emva kokukhulelwa kwesisu, unokuba uzimisele ukuzama malunga nayiphi nayiphi na ithuba xa lisebenza khona. Ukuba ulandela ukunyangwa kwamajoni omzimba okwee-NK ezisezantsi, qiniseka ukuba uqonda ukungaqiniseki kuphando kwaye usebenze kunye neengcali ezingaqinisekisiyo izithembiso ezingenangqiqo. Qinisekisa ukuba ulinganisela nayiphi na inzuzo efunyenweyo malunga nemingcipheko yonyango xa ukhulelwe.
Ukujamelana nokulahleka kwamathambo okuphindaphindiweyo kunzima kakhulu kwiindlela ezininzi. Kukho inkxalabo emininzi nangokwenyama ukuba abo bangakhange bajongane nale nto bayakwazi ukuqonda. Mhlawumbi ufumene iimpendulo ezaneleyo ukuba unganqikaza ukuphendula yakho ifowuni ngamanye amaxesha. Ngombulelo (okanye ngokudabukisayo) awunabo. Kukho uluntu oluhle kakhulu lwenkxaso yoluntu apho abafazi banokudibanisa nabanye "abaye khona" kwaye baqonde ezinye zeemvakalelo zabo abangenakho ukuqala ukuyiqonda.
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