Yintoni i-GnRH, indlela eSebenza ngayo, kunye noNyango lwe-GnRH
I-GnRH isichazizwi se-gonadotropin-release hormone. Le hormone ikhutshwa yi-hypothalamus kwingqondo.
I-GnRH isebenza kuma-receptors kwi-pituitary gland gland. I-GnRH ibonisa i-pituitary gland ukukhulula i- horonone ye - gonadotropin i-hormone (stimulating hormone) (i-FSH) kunye ne-hormone e-luteinizing ( LH ).
I-FSH kunye ne-LH ke sebenze kuma-ovari kumabhinqa nakwii-testes kumadoda.
Zenza ii-ovari zikhule kwaye zivuthise amaqanda, kwaye, kumadoda, ziqalise iimvavanyo ukuba zivuthwe kwaye zivelise ummi.
I-FSH ne-LH nayo ikhuthaza ama-ovari kunye nee-testes ukukhulula ama-hormone abo.
- Kwiiyunithi, i-estrogen, i-progesterone kunye ne testosterone ziveliswa.
- Kwiimvavanyo, i-testosterone ne-estrogen ikhutshwa.
I-GnRH ikhutshwe kwiipulisi kwaye ingapheliyo.
Kwamadoda, la maphupha aya kwizinga elihle kakhulu.
Kula mabhinqa, ubukhulu beentlobo ziyahlukahluka ngokuxhomekeka apho umzimba usekupheleni komzi. Ngokomzekelo, ngaphambi kokuba kuqhutywe i-ovulation, i-GnRH iqhuma rhoqo.
Amanye amagama kwiGnRH
- I-hormone-release hormone (LHRH)
- I-hormone-ukukhupha ihomoni
- I-Luliberin (unyango olunomdla olwenza njenge-GnRH emzimbeni)
- I-Gonadorelin (unyango olunomdla olwenza njenge-GnRH emzimbeni)
Uvavanyo kunye neGonadorelin
I-Gonadorelin yipilisi eyenza i-hormone GnRH emzimbeni.
Ingasetyenziselwa ukuvavanywa kwezonyango okanye njengonyango lokulibazisa okanye ukungahambi.
Ukuvavanya ngokuqhelekileyo kubandakanya ukufumana ijoyi yehomoni ngexesha elithile.
Okokuqala, uya kuba negazi, phambi kokujova ngehomoni.
Emva koko, ngexesha elithile, injoza ye-gonadorelin ingaphantsi kwesikhumba kwiinqununu ezinamafutha.
Emva koko, emva kwexesha elimiselweyo, uza kukhishwa igazi lakho kwakhona.
Le nkqubo - injola elandelwa yi-draw draw-iya kuqhubeka. Iziphumo ziya kuhlaziywa kwibhuyibhile.
Olu vavanyo lunokuthi lwenziwa kubantwana abanokubambezeleka kokutshatyalaliswa okanye abantu abadala abanokungalingani kwe-hormonal.
Unyango kunye neGonadorelin ngePut pump
Abasetyhini abangenayo i-ovulating banokuphathwa ngegonadorelin ngePump pump. Oku kwenziwa xa ukungabikho kwe-GnRH yimbangela yokugcoba.
Amadoda angavelisi isidoda angaphinda aphathwe nePut pump.
Umpompo unikela umthamo olinganisiweyo rhoqo imizuzu engama-90 kwixesha leveki.
Emva kokuqala kwonyango, kwabasetyhini, ngokuqhelekileyo kuthatha iiveki ezimbini ukuya kwethathu ukuze i-ovulation ivele. Emva kokuvuthwa kwegazi, unyango luhlala luqhubeka kwezinye iiveki ezimbini ngokusebenzisa isigaba esilandelayo.
GnRH-Are Are GnRH Agonists kunye neAntagonists
Ngexesha lokunyanga kwe-IVF , ugqirha wakho wokuzala ufuna ukulawula umjikelezo we-ovulatory. Ngaphandle koko, amaqanda angakhanjiswa ngokukhawuleza. Abayi kukwazi ukubuyiswa kunye nokucoca kwibhubhu ye-embryology ukuba oko kwenzeka.
Yingakho unokufuna ukuthatha i-GnRH agonist okanye uGnRH.
Zomibini zonyango zivelisa urhulumente wexeshana.
Umehluko phakathi kweziyobisi kukuba i-GnRH agonist kuqala ivelisa ukunyuka kwamaHhommoni e-FSH kunye ne-LH kwaye iyakumisa. Umphikisi we-GnRH akavelisi okokuqala.
Ngexesha le-IVF, ubuya kuzinika iinjenge ze-hormone ze-FSH ne-LH ukukhuthaza ii-ovari ukuvelisa amaqanda.
GnRH agonists ziquka:
- Lupron
- Umnayile
- Phakamisa
- Zoladex
GnRH zibandakanya:
- Antagon
- Ganirelix
- Orgalutran
- Cetrotide
I-GnRH i-agonists ingasetyenziselwa ukuphatha i- endometriosis kunye ne-fibroids.
> Imithombo:
> I-Gonadorelin (Umzila ongenayo, indlela yokugula). I-Micromedex Iinkcukacha ezichanekileyo zeDrug kuMthengi [Intanethi]. Health PubMed.
> I-Gonadotropin-Ukukhupha iHormone. Wena namaHormoni akho. Umbutho we-Endocrinology.
> Imithi yokukhupha i-Ovulation: Isikhokelo sabathinteli. Umbutho waseMelika weMithi yokuzala.