Ukuba uphando malunga nokukhulelwa kwesisu kubangele okanye ufumene umva okanye ubuninzi bokulahlekelwa ngamathambo, mhlawumbi uye wafunda ukuba oogqirha abanako ukuhlala bechaza isizathu sokuba kwenzeke. Enyanisweni, ngokwe-American College ye-Obstetrics kunye ne-Gynecology, i- miscarriages ephindaphindiweyo inobangela obonakalayo kuphela malunga nama-25 ukuya kuma-50 ekhulwini kwexesha.
Kukho iingcamango ezininzi malunga nento eyenza esinye isiqingatha seemeko zokukhulelwa kwexesha eliphindaphindiweyo, kodwa ezimbalwa zibonakaliswe ngokuqinisekileyo.
Enye imfundiso ewela kwicandelo lokugqibela kukuba amazinga aphezulu ehomoni okuthiwa i-prolactin inokubangela ukulahleka kokukhulelwa.
Xa ingxinano yegazi yeprolactin iphazamisa umsebenzi wama-ovari kumfazi wesandulela, ukufihla kwe-estradiol, i-estrogen ephezulu, iyancipha. Iimpawu ziquka ixesha elingenasiphelo okanye ukungabikho kwezikhathi, ukungabikho komzimba, iimpawu ze-menopausal (ukutshisa okutshisayo kunye nokomama wesisu) kwaye, emva kweminyaka emininzi, i-osteoporosis. Amanqanaba aphakamileyo e-prolactin angabangela ukukhishwa kwebisi kumabele.
Yintoni iprolactin?
Iprolactin i-hormone eveliswa ngokuyinhloko ngepeni le-pituitary yangaphambili, i-pea-size-scored base-bottom in the brain. Iprolactin ifumana igama layo kuba lidlala indima enkulu ekunciphiseni imveliso yobisi kubasetyhini abaqeshisayo. Amanqanaba eprolactin ngokuqhelekileyo akhula ngexesha lokukhulelwa komfazi, nangona amazinga ahluka kakhulu kubafazi. Amanqanaba e-prolactin afinyelela kwizinga eliphezulu kakhulu ngexesha lokuhanjiswa kwaye abuyele kwiimeko eziqhelekileyo kwiiveki ezintandathu emva kokuziswa (nangona ibhinqa libele).
Xa ama-prolactin aphakanyisiwe, le meko ibhalwe nge-hyperprolactinemia, kwaye la manqanaba aphezulu angaphazamisa indlela amaqanda omfazi asebenza ngayo. Oku kungakhokelela ekungeneni kwexesha, ukungabikho komntwana, kwaye ngezinye izikhathi ukukhululwa ubisi kwiibele, nangona umfazi engabalisi.
Isizathu esiqhelekileyo se-hyperprolactinemia yi-tumor e-non-cancerous tumor ebizwa ngokuba yi-adenoma, kodwa imeko ingafumaneka nakwabanye abantu abane-hypothyroidism.
Iprolactin inokuphakanyiswa kwakhona ekuphenduleni iziganeko zendalo, ezifana nokuzivocavoca ngamandla okanye ukuxinezeleka, kunye nabantu abathabatha imichiza echaphazela ingqondo yemichiza, i-dopamine.
Indima yoLuntu
Ngenxa yokuba isisitya kunye nomjikelezo oqhelekileyo wokujikeleza ovuthiweyo unqanda ngexesha lokutya, iprolactin yenza njengento yokukhulelwa kwemvelo ekhusela ukukhulelwa emva kokubuya. Oko kuthethwa, amazinga omzimba wakho weprolactin akufanele axhomekeke njengendlela yokukhulelwa ngokufanelekileyo. Qinisekisa ukuba uxoxe ngokukhulelwa kwe-postpartum kunye nomboneleli wakho wezempilo.
Ngokwale ngcamango eyamkelekileyo ukuba amazinga aphakamileyo e-prolactin angaphazamisa umsebenzi we-ovarian, abafazi abanamazinga aphezulu aseprolactin abazama ukukhulelwa banokufumana imijikelezo yesisini kunye / okanye ye-ovulatory engavamile, okwenza kube nzima ukukhulelwa.
Xa kuziwa kwi-prolactin kunye neengcambu zokulahleka eziqhelekileyo , nangona kunjalo, i-jury isaphuma. Izifundo ezimbalwa zifumene amanqanaba aphakamileyo e-prolactin kubasetyhini abaneemfucuza eziphindaphindiweyo. Oko kuthethwa ngolu hlobo kuthetha, nangona kunjalo, ingxabano. Abanye abantu bacinga ukuba iprolactin ephakamileyo inokubangela ukulahleka kwamathambo, ngelixa abanye bacinga ukuba kusekuseni kakhulu ukuthetha ngokucacileyo.
KwiNkxaso yeTheory
Ngenxa yokusebenzisana kwama-hormone amaninzi emzimbeni womntu, kunokwenzeka ukuba ukungalingani kunokubangela iingxaki ezininzi.
Ekubeni i-hyperprolactinemia inokubangela ukuba i-miscarriages inabesifazana abathile, oogqirha abathile bangabhekisha izinga leprolactin yowesifazane kwaye banike amayeza ukuba anciphise umgangatho ukuba uphakanyisiwe.
Kwimeko yezinto eziphambanisayo eziphambeneyo kunye neprolactin, olunye uphando oludala lufumene amanqanaba aphakamileyo e-prolactin kubasetyhini abanamabini okanye ukulahleka kokukhulelwa. Xa la mabhinqa aphathwe ngamachiza ebizwa ngokuthi i-bromocriptine (esebenzayo ekunciphiseni amanqanaba eprolactin) ekukhulelweni kwabo okuzayo, bekukho ama-85 ekhulwini azalwa ngokuzalwa ngokuthelekiswa nabasetyhini abangaphendulwanga abanamazinga angama-52 abaphila ngokuzalwa.
Ezi ziphumo azizange ziqinisekiswe kwisifundo esikhulu.
Kodwa, ngenxa yokuba unyango lucingelwa ukuba lukhuselekile, abanye oogqirha bavavanya kwaye baphatha iprolactin ephakamileyo xa bevavanya abasetyhini ngenxa yezizathu zokulahleka kwamathambo.
Ukuphikiswa kweNkolelo
Izifundo ezifumene unxibelelwano phakathi kwamanqanaba aphakamileyo e-prolactin kunye nokuphuphuma komzimba azikho ezinkulu ngokwaneleyo ukuba zifikeleleke.
Ukongeza, abaphandi abayiqondi ngokupheleleyo ukusebenza kweprolactin emzimbeni, kwaye abaninzi banomuva wokuba kusenokwenzeka ukuba kusenokwenzeka ukuba ingaba amazinga aphakanyisiweyo angama-prolactin abafazi abanezintlu ezingenayo imiphumo. Ezinye izinto zinokuthi zilandele iingxelo zezinga eliphezulu lamaplactin kumabhinqa anomzimba.
Apho ibeka khona
Abanye oogqirha bavame ukuvavanya iprolactin kwizibini ezithandanayo kunye neentlobo zeemferensi eziqhelekileyo kwaye zinike imithi, njenge-bromocriptine okanye i-cabergoline, ukunciphisa amanqanaba eprolactin. Ezi zonyango zibonakala zikhuselekile ukusetyenziswa ngexesha lokukhulelwa kwaye ziqhelekileyo zisetyenziselwa abafazi abangenabantwana abangenalo intsholongwane kwi-hyperprolactinemia. Oko kushiwo, akukho ziphakamiso ezisemthethweni zokuvavanya kunye nokunyanga iprolactin kubafazi abanobuhlungu obuphindaphindiweyo.
> Imithombo:
> Colao, Annamaria, Roger Abs, uDavid Gonzalez-Barcena, uPhillipe Chanson, uWolfgang Paulus kunye noDavid Kleinberg, "Iziphumo zokukhulelwa zilandelayo emva kokwelashwa kwe-cabergoline: kwandiswe kwiziphumo ezifundwe kwiminyaka eyi-12." I-Endocrinology yaseKliniki ngoJan 2008.
> Hirahara F, Andoh N, uSawai K, iHirabuki T, u-Uemura T, iMinaguchi H. Ukuphuphuma kwesisu ngokuphindaphindiweyo kunye neziphumo zezilingo zonyango ze-bromocriptine. Fertil Steril . Ngo-1998 Agasti; 70 (2): 246-52.
> Kaunitz, AM. (NgoJanuwari 2017). Ukukhulelwa kwesisu. Ku: UpToDate, i-Schreiber CA (Ed), UpToDate, i-Waltham, MA.
> IKomiti yokuSebenza ye-American Society yoMyeza ozalisayo. Ukuvavanywa kunye nokunyangwa kolahleko lokukhulelwa okuqhelekileyo: umbono wekomiti. Fertil Steril . NgoNovemba ka-2012; 98 (5): 1103-11.
> Snyder, PJ. (Novemba 2016). Iimbangela ze-hyperprolactinemia. Ku: UpToDate, Cooper DS (Ed), UpToDate, Waltham, MA.