Umngcipheko weCancer of Medicinal Drugs vs. Umngcipheko wokungafihlisi
Ngaba ukusetyenziswa kweziyobisi kubangela umdlavuza? Kuthiwani ngonyango lwe-IVF ? Kuyinyani ukuba iziphumo ezimbalwa zibonakala zifumana uxhamlwano phakathi kokusetyenziswa kweziyobisi kunye nenomngcipheko eyongezelelekileyo yomhlaza okanye isifo somhlaza, ngokukodwa kunye neziyobisi zeCommid .
Onke amayeza, kuquka ukusetyenziswa kweziyobisi, kuza neengozi.
Kodwa ngaba unokukhathazeka ngomngcipheko womhlaza? Makhe sibone.
Utywala Lwamachiza Unokwandisa ... okanye Unciphise Ingozi Yomhlaza Wakho?
Ngo-2005, uphando olupapashwe ngokubanzi lubhengeze ukuba ukusebenzisa i-Clomid kunokunyusa umngcipheko wesifo somhlaza.
Nangona kunjalo, ukususela ngeli xesha, kwenziwe uphando olongezelelweyo, kwaye uninzi alufumananga ukwanda okwenyathelo lomngcipheko womhlaza emva kokusetyenziswa kweComomid.
Enyanisweni, uvavanyo oluthile lubonisa ukuba abafazi abaphathwa ngokusetyenziswa kweziyobisi kubonakala babonisa umngcipheko wokunciphisa umhlaza wesibeleko xa kuthelekiswa nabasetyhini abangenabantwana abangafunanga unyango.
Olunye uphando lufumene umngcipheko wehla wokuba nomdlavuza webele emva koComomid.
Kutheni ukungahambelani?
Ingxaki ezininzi zezi zifundo azinakucinga ezinye izinto ezinobungozi bomdlavuza wesibeleko.
Ngokufanayo, ukuba ibhinqa lingaze likwazi ukukhulelwa, umngcipheko wakhe womhlaza uya kwanda.
Kwakhona, ukukhuluphala akuyona nje ingozi yokungabikho komntwana , kodwa yinto enobungozi yomhlaza.
Kungenzeka ukuba akuzange kube yiziyobisi zokuzala.
Esikhundleni salo, ukwanda kweemeko kunokuthi kubangelwa isizathu sokungabikho kwengqondo, okanye naliphi na leminye imiba engacatshangwanga kulolu cwaningo.
Uphando oluninzi lufumene unxibelelwano olunokwenzeka phakathi kwezinto ezithile zokungabikho komntwana kunye nokwanda komngcipheko womhlaza.
Enye ingxaki eqhelekileyo kulezi zifundo kukuba ubungakanani beesampula babuncinane kakhulu.
I-Clomid kunye namanye ama-Ovarian Ukukhuthazwa kwezidakamizwa kunye neengozi ze-Ovarian Cancer
Ubungqina obuqineleyo bokuthi i-Clomid kunye nezinye izidakamizwa ezivuselela i-ovarian ayinyuli umngcipheko wesibeleko se-ovari esivela kwi-Review yeKochrane, epapashwe ngo-2013.
Ukuhlaziywa kwakuquka izifundo ukusuka ngo-1990 ukuya kuFebhuwari 2013. Izifundo ezihlanganisiweyo kunye nabafazi abali-182,972.
Izifundo ezisixhenxe zifumananga ubungqina bonyango lomhlaza we-ovarian kwabasetyhini abasebenzisa nayiphi na into echaphazelekayo (kuquka iClomid) xa befanisa umngcipheko wabo nakwabanye abasetyhini abaneengxaki zokuzala abangazange basebenzise iziyobisi zokuzala.
Ngokutsho kokuhlaziywa, uphando olwalufumene umngcipheko wesifo somhlaza aluzange luthembeke ngenxa yokuba aluzange lucinge ngengozi yokungafumaneki ngokwabo okanye ubungakanani besampula abukancinci ukufikelela kwizigqibo.
Iimvumi ze-Ovarian kunye ne-IVF?
Ukuhlaziywa kweCochrane kwafumene ingozi eyongezelelekileyo yokunyuka kwamathambo e-ovarian boundary (ovarian tumors) kwiibhinqa ezadlulela unyango lwe-IVF.
Lo mngcipheko wawungekho emva kweComomid okanye iClomid kunye ne- gonadotropins unyango kuphela.
Unyango lwezitho zomzimba ze-ovarian torsary not as intense and involved in the tumors ovarian, kwaye ukuchaswa kwabasetyhini abane-tumor ephazamisayo kukuhle kakhulu.
Ucwaningo luka-2015 luzama ukuqhubela phambili uphando malunga nomngcipheko weengcambu ze-ovarian boundary and treatment treatment.
Into abayifumene kukuba kwakungekho nxu lumene phakathi kwee-tumor tumors kunye nokusetyenziswa kweziyobisi.
Nangona kunjalo, kunokuba noxhamlwano olunokwenzeka phakathi kwee-tumor tumors and supplementation.
Abaphandi bafumene ukuba umngcipheko wee-tumor ovarian tumors wawuphezulu kwabesetyhini abasebenzisa i-progesterone xa kuthelekiswa nabangakhange bawenze, kwaye phezulu kwabesetyhini abanezijikelezo ezine okanye ngaphezulu kwe-progesterone.
Oko kwathiwa, inani labasetyhini ekufundeni kunye neendumbu zamanqamzana.
Izifundo zokulandelelana ngamaqela amakhulu amabhinqa ayadingeka.
Ingozi yeCometerrial Cancer?
Ngaba iziyobisi zonyango zingandisa umngcipheko womhlaza we-endometrial?
Ukuhlaziywa kwe-Cochrane kweengxelo ezi-19 zaphetha ngokuthi ngenxa yoyilo oluthile olubi, akunakwenzeka ukuba uthethe ngokuqinisekileyo ukuba ingozi yomdlavuza we-endometrial yanda emva kokungena kwiziyobisi.
Kukho kubonakala ngathi ingozi inokunyuka kwabasetyhini abanamaqondo aphakamileyo kakhulu e-Clomid (ngaphezulu kwe-2,000 mg-isisindo sokuqala esisisigxina kuphela 50 mg) kwaye bathatha iComomid imijikelezo eyisixhenxe okanye ngaphezulu.
Nangona kunjalo, uphando lwangoku alukwazanga ukwahlula ukuba ingaba ingozi eyongeziweyo yenziwa ngenxa yeComomid okanye iimeko zokuzala. Umzekelo, i-PCOS yaziwa ngokunyusa umngcipheko wokwakha umdlavuza we-endometrial.
Umngcipheko wexesha elide lweCarcer Breast emva kwe-IVF
Ngaba unyango lwe-IVF lunokwandisa umngcipheko wesifo somhlaza? Uphando olutshanje luthi akunakwenzeka.
Uphando olukhulu kunamhlanje lubandakanya amabhinqa angama-25,108, ngokulandelelana okuphakathi kweminyaka engama-21 emva kokunyanga. Aba bafazi baseNetherlands, abafumana unyango lwe-IVF phakathi ko-1980 no-1995.
Kwakungabikho mngcipheko wesifo somhlaza webele kwabesetyhini abafumana i-IVF xa kuthelekiswa nalabo bafumana ezinye izibonelelo zonyango (kodwa hhayi i-IVF.)
Okuthakazelisayo, abaphandi bafumene ingozi yomhlaza wesifuba yayincinci kubafazi ababenemijikelezo engama-7 okanye ngaphezulu kwe-IVF xa kuthelekiswa nabasetyhini abane-1 okanye 2. Akucaci ukuba kutheni oku.
IVF ne-Ovarian Cancer
Kwinkomfa ye-American American Society for Reproductive Medicine (ASRM) nkomfa, uDkt. Alastair Sutcliffe weZiko leMpilo yabantwana kwiYunivesithi yaseLondon wanikezela uphando olujongene nomngcipheko womhlaza kubasetyhini abaye baphila nge- IVF .
Olu phofu lubandakanye abangaphezu kwama-250 000 amabhinqa aseBritani kwaye bajikeleza imijikelezo yonyango phakathi kuka-1991 no-2010.
Iindaba ezilungileyo kukuba abafumananga mngcipheko wesifo somhlaza okanye isifo somhlaza kwisifo se-IVF.
Iindaba ezimbi kukuba zifumene umngcipheko wokwanda komhlaza wesi-ovari.
Nangona abafazi ababengakaze bahambe nge-IVF babe ne-11 kwithuba elingu-10 000 lokuphucula umdlavuza we-ovari, izigulane ze-IVF zazinama-15 kwi-10 000.
Umngcipheko omncinci kodwa kubalulekile ukuqaphela.
Njengalezi zifundo ezikhankanywe ngentla, ukuvumelana kukuba ingozi eyongeziweyo ayibangelwa unyango lwe-IVF ngokwayo kodwa ukuba abafazi bafuna unyango.
Ukungenzi nto kwaye isidingo se-IVF sikhankanywa njengengozi. Akunjalo iziyobisi ezizaliswayo ngexesha lokunyanga.
Ngaloo nto, uphando lufumanise ukuba ingozi yomhlaza yayiphezulu kwiminyaka emithathu yokuqala emva kokonyango.
Ngoko, akunakwenzeka ukulawula ngokupheleleyo ukuba izidakamizwa zokuzala zidlala indima kwingozi yomhlaza. Ukuvavanya okufutshane kwiminyaka emva kokuba unyango lwe-IVF lube luncedo.
Akukho Mngcipheko ophezulu weCarcer
Uhlalutyo lweemeta luphando lophando oluqokelela ulwazi kwiinkalo ezininzi kwaye luvavanya kunye. IYunivesithi yase-Ottawa yenza i-meta-analysis ukuba ibone ukuba ukusetyenziswa kweziyobisi ezinobunzima kwandisa ingozi yomhlaza xa kuthelekiswa nabasetyhini abangenasifo abangazange baphathwe.
Uhlalutyo luquka iinkcukacha eziqokelelwe kwizifundo ezilishumi eziphando, kunye nolwazi malunga nabasetyhini abathwala izidakamizwa ezinjengeClomid, i- gonadotropins , i- chorionic gonadotropin (hCG) , kunye ne- gonadotropin-ukukhulula i-hormone agonists (GnRH).
Abaphandi bafumanisa ukuba xa kuthelekiswa nabasetyhini abangenabantwana abaphathwa ngamachiza okuzala, abachasene nabasetyhini abangazange baphathwe, abo baphathwa ngamachiza okuzala abazange bangene engozini yokwanda komhlaza wesibeleko.
Unomdla kakhulu, bafumanisa ukuba abafazi abaphathwayo babonakala benesifo esiphantsi somhlaza we-ovari xa kuthelekiswa nabasetyhini abangenabantwana abangazange baphathwe.
Kwesinye isifundo, eli liqhutywe yiDanmark Cancer Society, abaphandi bafunda ngokubanzi abafazi abangama-54,362 abangenasifo. (Ukufundwa kwamanye amaxesha xa bejonga iqela elikhulu labantu abaneemeko ezifanayo, ngokuqhelekileyo ngaphezu kwexesha elide.)
Kule sifundo, abaphandi abafumananga ukwanda okwenyuka kumngcipheko wesifo somhlaza emva kokusebenzisa iziyobisi, ngokukodwa i- gonadotrophins , i- Clomid , i- hCG , okanye i- GnRH .
Ezinye izifundo zifumene iziphumo ezifanayo.
Igama elivela kwi-Verywell
Ingavumelwane kukuba izidakamizwa zokuzala azikhulise umngcipheko wakho wokuphucula isifuba somhlaza okanye isifo somhlaza. Kwakhona, ezinye izifundo zijonge ukusetyenziswa kweziyobisi kunye nezinye iintlobo zeekritha (i-thyroid kunye ne-skin cancer, umzekelo), kwaye abafumananga ukwanda okwenyuka kumngcipheko.
Nangona kunjalo, ngenxa yokungabikho kwengqondo ngokwayo yinto engumngcipheko womhlaza, ukulandelelana emva kokuxilongwa kukucetyiswa.
Abasetyhini abanesifo sokuqala, abangakhange bakhulelwe baze bazalwe, kunye nabasetyhini abafumene ukuba ne- endometriosis , banokubeka ingozi enkulu yokuba nomhlaza.
I-PCOS , isizathu esivakalayo sokungabikho kwengqondo, kuyaziwa nangokuza kwengozi yokwanda komdlavuza we-endometrial. Kungenzeka ukuba amazinga aphezulu kakhulu e-Clomid, okanye unyango ogqithise ngaphezu kwemijikelezo yesixhenxe, inokunyusa umngcipheko womhlaza we-endometri. Kodwa ubungqina obukhoyo abukwazi ukwahlula ukuba ngaba lo mngcipheko okhulayo usuka kwiComidid okanye ukungazinzi ngokwalo.
Kwakhona kubalulekile ukugcina engqondweni ukuba iteknoloji yokunyanga kwenyango iyatshintsha. Amanyathelo angaphantsi kwezi yobungozi asetyenziswa ngokusesikweni kwimihla yokuqala yonyango , kwaye ezininzi zezifundo malunga nomhlaza kunye nokunyanga kwenzalo zibandakanya abafazi baphathwa ngama-1980s, ngokugqithiseleyo kunokuba banokuba namhlanje.
Uphononongo olwenziwe ngumhlaza kunye nokonyango lwezityalo lufuna ukulandelelwa kwexesha elide. Kusenokuba mashumi eminyaka ngaphambi kokuba sitsho ukuba yintoni impembelelo yokunyanga kwenzalo kwiminyaka engama-35 iya kuba nomfazi oneminyaka engama-65 okanye eyi-70 ubudala. Nangona uphando oluninzi lufuneka lwenziwe, okwangoku, iziyobisi zonyango (ikakhulukazi) ziphuma kwikhoko.
> Imithombo:
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> Van den Belt-Dusebout AW1, Spaan M1, i-Lambalk CB2, i-Kortman M3, i-Jven 4, i-valve JS4, i-van Santbrink i-EJ5, i-van der Westerlaken i -6, i-Cohlen i-JJ, i-Braat DD8, i-Smeenk JM9, i-Land JA10, i-Goddijn M11, i-van Golde iJJ12 i-van Rumste MM13, Schats R2, Józwiak K1, Hauptmann M1, Rookus MA1, Burger CW4, van Leeuwen FE1. "Ukunyanzeliswa kwe-Ovarian kwi-Vitro Fertilization kunye neKuhlala kwengozi yentsholongwane ye-Breast Cancer. "JAMA. 2016 Julayi 19; 316 (3): 300-12. i-doi: 10.1001 / jama.2016.9389.